4,4'-Dichlorobenzhydrol → 4,4'-Dichlorobenzhydryl chloride

HRID 231212

반응식

HRID 231212 반응식
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:20]=[CH:19][C:9]([CH:10](O)[C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1>>[Cl:5][C:6]1[CH:20]=[CH:19][C:9]([CH:10]([Cl:3])[C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1

참가 물질

3

반응물 2

HCID 70334,4'-DichlorobenzhydrolHCID 24386Thionyl Chloride

생성물 1

HCID 130784,4'-Dichlorobenzhydryl chloride

실험 절차

Forty-two milliliters of thionyl chloride were gradually added to 75 g of 4,4'-dichlorobenzhydrol. When the addition was complete, the reaction was heated on a steam bath for 2 hours. The excess thionyl chloride was removed in vacuo. One hundred milliliters of carbon tetrachloride were added, and the solvent was again evaporated. The carbon tetrachloride treatment was repeated and upon evaporation the resulting oil was crystallized from petroleum ether to provide 65.3 g of the desired sub-titled intermediate, m.p. 63° C.

후처리

  1. additionWhen the addition
  2. temperaturethe reaction was heated on a steam bath for 2 hours
  3. customThe excess thionyl chloride was removed in vacuo
  4. additionOne hundred milliliters of carbon tetrachloride were added
  5. customthe solvent was again evaporated
  6. customThe carbon tetrachloride treatment was repeated and upon evaporation the resulting oil
  7. customwas crystallized from petroleum ether

출처 및 근거

ORD 기록
ord-816a8a416f95473299bb77d8e4cf6ead
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845227

연결된 노트

불러오는 중…