trans-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone → trans-4-Acetoxy-3-(1-hydroxyethyl)-2-azetidinone

HRID 231231노트

반응식

HRID 231231 반응식
[C:1]([O:4][C@@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[CH:10]([O:12][Si](C(C)(C)C)(C)C)[CH3:11])(=[O:3])[CH3:2]>C(O)(=O)C.O>[C:1]([O:4][C@@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[CH:10]([OH:12])[CH3:11])(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 67757824trans-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

생성물 1

HCID 67789253trans-4-Acetoxy-3-(1-hydroxyethyl)-2-azetidinone수율 24.9%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

Trans-4-acetoxy-3-[1-(tert-butyldimethylsilyloxy)-ethyl]-2-azetidinone (0.20 g) is dissolved in a mixture of acetic acid (5 ml) and water (2 ml), and the solution is stirred at 70°-80° C. for 2.5 hours and then concentrated under reduced pressure. The residue is subjected to silica gel column chromatography to give 0.03 g of trans-4-acetoxy-3-(1-hydroxyethyl)-2-azetidinone.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d0ad439e23884e80974957d04dd3358d
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845210

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