Methanol → L-Cysteine, methyl ester, hydrochloride

HRID 231249

반응식

[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[CH3:12][O:6][C:5](=[O:7])[C@H:2]([CH2:3][SH:4])[NH2:1]

참가 물질

반응물 3

HCID 887Methanol

HCID 5862L-(+)-Cysteine2회

HCID 24386Thionyl Chloride

생성물 1

HCID 2733208L-Cysteine, methyl ester, hydrochloride

반응 조건

온도: -78 °C

실험 절차

To a suspension of (R)-cysteine (40.0 g, 0.330 mole) in 400 ml of methanol maintained under nitrogen at -78° C. was added thionyl chloride (28 ml, 0.384 mole). The cysteine slowly dissolved to form a clear solution. The solution was stirred overnight at room temperature and then evaporated under vacuum to yield (R)-cysteine methyl ester hydrochloride as a colorless, sticky syrup (57.0 g, 100% yield). The product solidified upon standing.

후처리

customto form a clear solution
customevaporated under vacuum

출처 및 근거

ORD 기록: ord-29fd4b4006094e4d999d83bf6df40d72
출처 데이터셋: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04845229

연결된 노트

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