Dichloromethane → 2-Methoxy-3-octadecyloxypropyl methanesulfonate

HRID 231255

반응식

HRID 231255 반응식
ClCCl.[CH3:4][O:5][CH:6]([CH2:9][O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:7][OH:8].[CH3:29][S:30](Cl)(=[O:32])=[O:31]>C(N(CC)CC)C>[CH3:29][S:30]([O:8][CH2:7][CH:6]([O:5][CH3:4])[CH2:9][O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])(=[O:32])=[O:31]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 3364221-Propanol, 2-methoxy-3-(octadecyloxy)-

생성물 1

HCID 145010372-Methoxy-3-octadecyloxypropyl methanesulfonate수율 100%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To 120 ml of dichloromethane are added 12.0 g of 2-methoxy-3-octadecyloxypropanol and 6.07 ml of triethylamine, to which 4.98 g of methanesulfonyl chloride is added dropwise with stirring under ice cooling. Thereafter, the mixture is stirred at room temperature for 2 hours to complete the reaction. The reaction mixture is then washed with water, an aqueous sodium bicarbonate solution and again water and dried over anhydrous sodium sulfate. The solvent is distilled off under reduced pressure to leave 14.6 g (100%) of the captioned compound.

후처리

  1. stirringThereafter, the mixture is stirred at room temperature for 2 hours
  2. customthe reaction
  3. washThe reaction mixture is then washed with water
  4. dry with materialan aqueous sodium bicarbonate solution and again water and dried over anhydrous sodium sulfate
  5. distillationThe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-0463feb32d9745479a5b23a92d5682b6
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845219

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