Triethylamine → 3-Mesyloxypropyl 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl sulfone

HRID 231272노트

반응식

HRID 231272 반응식
[OH:1][CH2:2][CH2:3][CH2:4][S:5]([CH2:8][CH:9]([O:30][CH3:31])[CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)(=[O:7])=[O:6].C(N(CC)CC)C.[CH3:39][S:40](Cl)(=[O:42])=[O:41]>ClCCl>[CH3:31][O:30][CH:9]([CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1)[CH2:8][S:5]([CH2:4][CH2:3][CH2:2][O:1][S:40]([CH3:39])(=[O:42])=[O:41])(=[O:7])=[O:6]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 536553312-Methoxy-3-(12-cyclohexyldodecyloxy)propyl 3-hydroxypropyl sulfone

생성물 1

HCID 200348483-Mesyloxypropyl 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl sulfone수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In 100 ml of dichloromethane are dissolved 8.9 g of 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl 3-hydroxypropyl sulfone and 3.7 ml of triethylamine, to which 3.0 g of methanesulfonyl chloride is added dropwise with stirring under ice cooling. After 2 hours stirring at room temperature, the reaction solution is washed with water, an aqueous sodium bicarbonate solution and water, and dried. The solvent is then distilled off under reduced pressure to leave 10.4 g of the captioned compound.

후처리

  1. stirringAfter 2 hours stirring at room temperature
  2. washthe reaction solution is washed with water
  3. dry with materialan aqueous sodium bicarbonate solution and water, and dried
  4. distillationThe solvent is then distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-7b72b371a23642eb80240b8937b93466
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845219

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