2-(6-Azidopyrimidin-4-yloxy)ethanol → 2-((6-Aminopyrimidin-4-yl)oxy)ethanol
반응식
[N:1]([C:4]1[N:9]=[CH:8][N:7]=[C:6]([O:10][CH2:11][CH2:12][OH:13])[CH:5]=1)=[N+]=[N-]>[C].[Pd].C(O)C>[NH2:1][C:4]1[N:9]=[CH:8][N:7]=[C:6]([O:10][CH2:11][CH2:12][OH:13])[CH:5]=1참가 물질
4
실험 절차
A mixture of 2-(6-azidopyrimidin-4-yloxy)ethanol (1.64 g), 10% palladium-carbon (0.25 g) and ethanol (20 ml) is subjected to catalytic hydrogenation at room temperature for one hour under hydrogen atmosphere (1 atm). The catalyst is removed by filtration, and the filtrate is concentrated. The residue is recrystallized from ethanol/diethyl ether to give 2-(6-aminopyrimidin-4-yloxy)ethanol (1.11 g).
후처리
- customThe catalyst is removed by filtration
- concentrationthe filtrate is concentrated
- customThe residue is recrystallized from ethanol/diethyl ether
출처 및 근거
- ORD 기록
- ord-fa1f51d360144913905861053111ec80
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05728706
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