Dichloromethane → 5-Amino7-(2-methylpropyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one Hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	Dichloromethane	HCID 6344	—
반응물	Isobutyl iodide	HCID 10556	—
반응물	Cesium carbonate	HCID 10796	—
반응물	5-(N-Boc-amino)-5,7-dihydro-6H-dibez[b,d]azepin-6-one	HCID 11493548	—
용매	Dimethylformamide	HCID 6228	—
생성물	5-Amino7-(2-methylpropyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one Hydrochloride	HCID 22288314	—

반응 조건

온도	60 °C

반응 단계

A solution of 5-(N-Boc-amino)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (0.2 g, 0.617 mmol) (Example 7-E) in DMF was treated with Cs2CO3 (0.22 g, 0.678 mmol) and warmed to 60° C. To the reaction mixture was added 1-iodo-2-methylpropane (0.078 ml, 0.678 mmol) and stirring continued for 17 h. After cooling to 23° C. the mixture was diluted with CH2Cl2, washed with several portions of brine and dried over Na2SO4. The title compound was purified by chromatography (SiO2, CHCl3/MeOH 9:1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06849650B2
출처 데이터셋	uspto-grants-2005_02
ORD ID	ord-7aeb8ae534b34973b7a463f3df84db89
출처 메모	uspto-grants-2005_02