Dichloromethane → 5-amino-7-(methoxyacetyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	Dichloromethane	HCID 6344	—
반응물	Cesium carbonate	HCID 10796	—
반응물	Bromomethyl acetate	HCID 68536	—
반응물	5-(N-Boc-amino)-5,7-dihydro-6H-dibez[b,d]azepin-6-one	HCID 11493548	—
용매	Dimethylformamide	HCID 6228	—
생성물	5-amino-7-(methoxyacetyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one hydrochloride	HCID 22312635	—

반응 조건

온도	60 °C

반응 단계

A solution of 5-(N-Boc-amino)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (1.03, 3.08 mmol) (Example 7-E) in DMF was treated with Cs2CO3 (1.10 g, 3.39 mmol) and warmed to 60° C. To the reaction mixture was added bromomethyl acetate (0.321 ml, 3.39 mmol) (Aldrich) and stirring continued for 17 h. After cooling to 23° C. the mixture was diluted with CH2Cl2, washed with several portions of brine and dried over Na2SO4. The title compound was purified by chromatography (SiO2, CHCl3).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06849650B2
출처 데이터셋	uspto-grants-2005_02
ORD ID	ord-aa5db1a52ef141b09e1c109095bb69a8
출처 메모	uspto-grants-2005_02