Isobutyl iodide → 1,3-dihydro-1-isobutyl-5-phenyl-2H-1,4-benzodiazepin-2-one

HRID 23137

반응식

[C:1]1([C:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[NH:11][C:10](=[O:18])[CH2:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:19](I)[CH:20]([CH3:22])[CH3:21]>>[CH2:19]([N:11]1[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8][CH2:9][C:10]1=[O:18])[CH:20]([CH3:22])[CH3:21]

참가 물질

반응물 2

HCID 10556Isobutyl iodide

HCID 76175RO-05-2921

생성물 1

HCID 223120251,3-dihydro-1-isobutyl-5-phenyl-2H-1,4-benzodiazepin-2-one

실험 절차

1,3-Dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one (prepared according to the procedure of M. G. Bock et al., J. Org. Chem. 1987, 52, 3232-3239) was alkylated with isobutyl iodide using General Procedure 8-G to afford 1,3-dihydro-1-isobutyl-5-phenyl-2H-1,4-benzodiazepin-2-one.

출처 및 근거

ORD 기록: ord-79b8a398bd8e45f69749c2c7ec69f0df
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06849650B2

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