Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-[(2-Chloro-4-fluorophenyl)methyl]-4,4-dimethyl-1,2-oxazolidin-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4,4-Dimethyl-1,2-oxazolidin-3-one | HCID 642151 | — |
| 반응물 | 1-(Bromomethyl)-2-chloro-4-fluorobenzene | HCID 2725062 | — |
| 촉매 | 18-Crown-6 | HCID 28557 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-[(2-Chloro-4-fluorophenyl)methyl]-4,4-dimethyl-1,2-oxazolidin-3-one | HCID 13192573 | 107.5% |
반응 단계
By the method of Example 6, Step B, 95.6 g (0.83 mole) of 4,4-dimethyl-3-isoxazolidinone, 186 g (0.83 mole) of 2-chloro-4-fluorobenzyl bromide, 114.7 g (0.83 mole) of potassium carbonate, and 2.2 g (0.008 mole) of 1,4,7,10,13,16-hexaoxacyclooctadecane were reacted at room temperature in 1500 ml of acetonitrile, yielding 230 g of impure 2-[(2-chloro-4-fluorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone. The nmr spectrum was consistent with the proposed structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04846882 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-032edfa95986474791a59a65cc58daa4 |
| 출처 메모 | uspto-grants-1989_07 |