Tetramethoxypropane → Ethyl pyrazolo(1,5-a)pyrimidine-3-carboxylate

HRID 231521

반응식

HRID 231521 반응식
[NH2:1][C:2]1[NH:6][N:5]=[CH:4][C:3]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].CO[CH:14](OC)[CH2:15][CH:16](OC)OC>C(O)(=O)C>[N:5]1[N:6]2[CH:14]=[CH:15][CH:16]=[N:1][C:2]2=[C:3]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:4]=1

참가 물질

4

반응물 2

HCID 66019TetramethoxypropaneHCID 81472ethyl 3-amino-1H-pyrazole-4-carboxylate

생성물 1

HCID 7021267Ethyl pyrazolo(1,5-a)pyrimidine-3-carboxylate수율 58.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A stirred mixture of 10.88 g of 5-amino-4-pyrazolecarboxylic acid, ethyl ester, 11.51 g of malonaldehyde bis(dimethyl acetal) and 100 ml of glacial acetic acid was heated at reflux for 16 hours, then worked up as described in Example 50 to give 7.8 g of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, ethyl ester.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours

출처 및 근거

ORD 기록
ord-5f8b8cdbe5c44c21aa1db52de5971b43
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847256

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