Tetramethoxypropane → Phenylpyrazolo[1,5-a]pyrimidin-3-yl-methanone

HRID 231522

반응식

HRID 231522 반응식
[NH2:1][C:2]1[C:6]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])=[CH:5][NH:4][N:3]=1.CO[CH:17](OC)[CH2:18][CH:19](OC)OC>C(O)(=O)C>[C:9]1([C:7]([C:6]2[CH:5]=[N:4][N:3]3[CH:19]=[CH:18][CH:17]=[N:1][C:2]=23)=[O:8])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 66019TetramethoxypropaneHCID 178509267HCID 178509267, 화합물

생성물 1

HCID 14501871Phenylpyrazolo[1,5-a]pyrimidin-3-yl-methanone수율 76.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 1.87 g of (3-amino-1H-pyrazol-4-yl)phenylmethanone (prepared as described in U.S. Patent application Ser. No. 612,811, filed May 24, 1984), 1.64 g of malonaldehyde bis(dimethyl acetal) and 25 ml of glacial acetic acid was heated at reflux for 6 hours. The solvent was evaporated and the solid was worked up as described in Example 50 and gave 1.70 g of phenylpyrazolo[1,5-a]pyrimidin-3-yl-methanone, mp 174°-175° C.

후처리

  1. customprepared
  2. temperaturewas heated
  3. temperatureat reflux for 6 hours
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-b23b74c296514f06aafdba5207a5e044
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847256

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