Acetic Acid → 2-Furanylpyrazolo[1,5-a]pyrimidin-3-yl-methanone

HRID 231523

반응식

HRID 231523 반응식
[NH2:1][C:2]1[C:6]([C:7]([C:9]2[O:10][CH:11]=[CH:12][CH:13]=2)=O)=[CH:5][NH:4][N:3]=1.CO[CH:16](OC)[CH2:17][CH:18](OC)OC.C(O)(=[O:27])C>>[O:10]1[CH:11]=[CH:12][CH:13]=[C:9]1[C:7]1[C:6]([CH:5]=[O:27])=[C:2]2[N:1]=[CH:16][CH:17]=[CH:18][N:3]2[N:4]=1

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 66019TetramethoxypropaneHCID 178509268HCID 178509268, 화합물

생성물 1

HCID 822718692-Furanylpyrazolo[1,5-a]pyrimidin-3-yl-methanone

실험 절차

A mixture of 7.08 g of (3-amino-1H-pyrazol-4-yl)-2-furanylmethanone (prepared as described in U.S. Pat. appliction Ser. No. 612,811, filed May 24, 1984), 8.20 g of malonaldehyde bis(dimethyl acetal) and 100 ml of glacial acetic acid was heated at reflux for 8 hours. The solvent was evaporated and the solid was worked up as described in Example 50 to give 4.92 g of 2-furanylpyrazolo[1,5-a]pyrimidin-3-yl-methanone, mp 222°-224° C.

후처리

  1. customprepared
  2. temperaturewas heated
  3. temperatureat reflux for 8 hours
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-58e77f51c267468382dcf0b9409dafb9
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847256

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