Ethanone, 1-(2,5-dichlorophenyl)- → 1-(2,5-Dichlorophenyl)-3-(dimethylamino)-2-buten-1-one
반응식
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:5]=1[Cl:11])=[O:3].CO[C:14](OC)([N:16]([CH3:18])[CH3:17])[CH3:15]>>[Cl:11][C:5]1[CH:6]=[CH:7][C:8]([Cl:10])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[C:14]([N:16]([CH3:18])[CH3:17])[CH3:15]참가 물질
3
실험 절차
A mixture of 50.0 g of 2,5-dichloroacetophenone and 50 ml of N,N-dimethylacetamide dimethyl acetal was stirred and heated at reflux for 121/2 hours. The mixture was then cooled and evaporated in vacuo to give an oil which crystallized on scratching to give a dark red solid. This was collected and washed with hexane/ether to give 58.8 g of 1-(2,5-dichlorophenyl)-3-(dimethylamino)-2-buten-1-one as a red solid.
후처리
- temperatureheated
- temperatureat reflux for 121/2 hours
- temperatureThe mixture was then cooled
- customevaporated in vacuo
- customto give an oil which
- customcrystallized
- customto give a dark red solid
- customThis was collected
- washwashed with hexane/ether
출처 및 근거
- ORD 기록
- ord-d99d1f8bdac04dbda8b5dddd5f1ebae5
- 출처 데이터셋
- uspto-grants-1989_07
- 특허 번호
- US04847256
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