Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Chlorophenacyl bromide → 8-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Chlorophenacyl bromide | HCID 68303 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 3-Bromo-5-chloropyridin-2-amine | HCID 2763971 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 8-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine | HCID 14234917 | — |
반응 단계
17 g (82 mmol) of 2-amino-3-bromo-5-chloropyridine dissolved in 150 ml of ethanol are reacted with 29 g of 2-bromo-1-(4-chlorophenyl)-1-ethanone and 14 g of sodium hydrogen carbonate. The mixture is brought to the refluxing temperature for 6 h and cooled. The precipitate is filtered off and rinsed with CH2Cl2, and the filtrate is concentrated under reduced pressure. After recrystallization of the evaporation residue in ethyl acetate, the compound melts at 178° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04847263 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-8a2f27f02afd4b7b85817dfa22b20cfb |
| 출처 메모 | uspto-grants-1989_07 |