Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 3-Iodomethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | 3-Chloromethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione | HCID 20033479 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 3-Iodomethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione | HCID 20033544 | 92% |
반응 단계
A solution of 15.2 g (0.06 moles) 3-chloromethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione (according to Example 1) and 10.7 g (0.066 moles) sodium iodide in acetone were refluxed for 8 hours in acetone. The precipitated sodium chloride was then filtered off, and the filtrate was concentrated, extracted with chloroform and the extract once more concentrated. The desired product was obtained in a yield of 92%. Melting point: 156° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04847285 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-24dd3ef3458d4214aa2f8d4a0a3fc612 |
| 출처 메모 | uspto-grants-1989_07 |