Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Sulfate → Ethyl 2-amino-6-nitrobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Sulfate | HCID 6163 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Amino-6-nitro-benzoic acid | HCID 95795 | — |
| 생성물 | Ethyl 2-amino-6-nitrobenzoate | HCID 20033751 | — |
반응 단계
A solution of 2-amino-6-nitrobenzoic acid (29.2 g, 0.16 mol), diethylsulfate (24.7 g, 0.160 mol) and triethylamine (16.2 g, 0.160 mol) in N-dimethylformamide (250 ml) was stirred at 20-25° for 20 hours. After removing DMF at 60° and 0.2 mm pressure, the residue was flash chromotographed over silica gel and the ethyl ester (10.8 g) eluted first with toluene then with 50% toluene-50% chloroform.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04847294 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-c2b21851377d4ef093985a94dcaa0ab0 |
| 출처 메모 | uspto-grants-1989_07 |