Dimethylamine → N,N-dimethyl-(2-pyridyl)acetamide

HRID 231596

반응식

HRID 231596 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O:10]CC)=O.[CH3:13][NH:14][CH3:15]>CO>[CH3:13][N:14]([CH3:15])[C:8](=[O:10])[CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 75960Ethyl 2-pyridylacetate

생성물 1

HCID 10678588N,N-dimethyl-(2-pyridyl)acetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 5.0 g of ethyl 2-pyridylacetate dissolved in 25 ml of MeOH was added 20 ml of dimethyl amine. The mixture was heated at 90° in a steel autoclave for 96 hrs. The solvent/amine mixture was allowed to evaporate until a residual oil was obtained. The residual oill was distilled to afford 4.5 g of the desired N,N-dimethyl-(2-pyridyl)acetamide as a free-flowing yellow oil, bp 105°-110°/0.5 mm.

후처리

  1. customto evaporate until a residual oil
  2. customwas obtained
  3. distillationThe residual oill was distilled

출처 및 근거

ORD 기록
ord-fbe29130b7af45a0ad8bdbdccc5f2df4
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847301

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