참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 5-Bromo-2-thiophenesulfonamide | HCID 1241304 | — |
| 반응물 | 4-Mercaptophenylacetic acid | HCID 3390511 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-(4-Carboxymethylphenylthio)thiophene-2-sulfonamide | HCID 20033693 | — |
반응 단계
4-Mercaptophenylacetic acid (2.3 g) was dissolved in dimethylformamide under a nitrogen atmosphere and 1.8 g of potassium hydroxide dissolved in a minimum amount of water was added. 5-bromothiophene-2-sulfonamide (3.3 g) dissolved in dimethylformamide was added and the mixture heated at 120° C. for 2 hours. After cooling to room temperature water was added to the reaction mixture, the pH was adjusted to 8.6 and the mixture was extracted with ethyl acetate. The aqueous phase was separated and acidified, causing a solid to precipitate. The solid was collected by filtration and dried under vacuum to a weight of 3.25 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04847289 |
|---|
| 출처 데이터셋 | uspto-grants-1989_07 |
|---|
| ORD ID | ord-e9ec0aeb8d5c4266906869950d3ea639 |
|---|
| 출처 메모 | uspto-grants-1989_07 |
|---|
