2-Chloropyrimidine → 3-[4-(Pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol

HRID 231762노트

반응식

HRID 231762 반응식
[OH:1][CH:2]([CH2:10][OH:11])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.Cl[C:13]1[N:18]=[CH:17][CH:16]=[CH:15][N:14]=1>O1CCOCC1>[N:14]1[CH:15]=[CH:16][CH:17]=[N:18][C:13]=1[N:7]1[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][OH:11])[CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 744042-ChloropyrimidineHCID 1110023-(Piperazin-1-yl)propane-1,2-diol

생성물 1

HCID 200319993-[4-(Pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Grams 3.2 of 1-(2,3-dihydroxypropyl)piperazine and 1.14 g of 2-chloropyrimidine in 50 ml dioxane were refluxed for two and a half hour. The reaction mixture was then settled and the solution evaporated to dryness. The residue obtained was extracted with hot acetone and filtered to remove all impurities. After resting 1.1 g of 3-[4-(pyrimidin-2-yl)piperazin-1-yl]propane-1,2-diol were separated, which melted at 118°-120° C.

후처리

  1. customthe solution evaporated to dryness
  2. customThe residue obtained
  3. extractionwas extracted with hot acetone
  4. filtrationfiltered
  5. customto remove all impurities
  6. customwere separated

출처 및 근거

ORD 기록
ord-25bdf0bbd7a74db187d6766b64822a0d
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04849422

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