2-Chloronicotinamide → 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinamide
반응식
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[OH:11][CH:12]([CH2:20][OH:21])[CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(O)C>[OH:11][CH:12]([CH2:20][OH:21])[CH2:13][N:14]1[CH2:19][CH2:18][N:17]([C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([NH2:6])=[O:5])[CH2:16][CH2:15]1참가 물질
4
실험 절차
Operation was carried out in a manner similar to the one described in Example 2, using 1.6 g of 2-chloronicotinamide, 3.2 g of 1-(2,3-dihydroxypropyl)piperazine and 30 ml ethanol and refluxing overnight. Column purification of the residue gave 1 g of 2-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinamide, which, recrystallized from acetone, melted at 140°-142° C.
후처리
- temperaturerefluxing overnight
- customColumn purification of the residue
출처 및 근거
- ORD 기록
- ord-0ef617aa10c541aea1bf538ef375577c
- 출처 데이터셋
- uspto-grants-1989_07
- 특허 번호
- US04849422
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