Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloronicotinic acid → 2-{4-[2-(2-Hydroxy ethoxy)ethyl]piperazin-1-yl}nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloronicotinic acid | HCID 76258 | — |
| 반응물 | 1-[2-(2-Hydroxyethoxy)ethyl]piperazine | HCID 139436 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-{4-[2-(2-Hydroxy ethoxy)ethyl]piperazin-1-yl}nicotinic acid | HCID 20032014 | — |
반응 단계
Grams 5.9 of 1-(2-hydroxyethoxyethyl)piperazine and 2.7 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 3 days. The reaction mixture was then cooled and allowed to rest for 2 days, afterwards the solvent was removed and the residue crystallized from absolute ethanol, gave 1.1 g of 2-{4-[2-(2-hydroxy ethoxy)ethyl]piperazin-1-yl}nicotinic acid melting at 172°-174° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04849422 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-3a6e8d7cf8b340888fd9d3b28157e5fc |
| 출처 메모 | uspto-grants-1989_07 |