Imidazole → Pyrimidine, 2,4-di-1H-imidazol-1-yl-

HRID 231789노트

반응식

HRID 231789 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCCC1>[N:9]1([C:2]2[N:7]=[C:6]([N:9]3[CH:13]=[CH:12][N:11]=[CH:10]3)[CH:5]=[CH:4][N:3]=2)[CH:13]=[CH:12][N:11]=[CH:10]1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 775312,4-Dichloropyrimidine

생성물 1

HCID 10751012Pyrimidine, 2,4-di-1H-imidazol-1-yl-수율 76.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In anhydrous tetrahydrofuran, 149 mg of 2,4-dichloropyrimidine was substituted with 136 mg of imidazole. The reaction mixture was treated according to the procedure of Example 1 to yield 163 mg of 2,4-bis(1-imidazolyl)pyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, the compound had a melting point of 131°-132° C.

후처리

  1. additionThe reaction mixture was treated

출처 및 근거

ORD 기록
ord-042e58c582b441edafece2dd51d7938a
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04849424

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