Imidazole → 2-chloro-4-(1H-imidazol-1-yl)pyrimidine
반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCCC1>[Cl:1][C:2]1[N:7]=[C:6]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH:5]=[CH:4][N:3]=1참가 물질
4
실험 절차
In anhydrous tetrahydrofuran, 680 mg of 2,4-dichloropyrimidine was substituted with 680 mg of imidazole. The reaction mixture was then treated according to the procedure of Example 5 to yield 840 mg of the 2-chloro-4-(1-imidazolyl)pyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, having a melting point of 127.5°-128° C.
후처리
- additionThe reaction mixture was then treated
출처 및 근거
- ORD 기록
- ord-b4444250b0d64839955316a3506c0fd3
- 출처 데이터셋
- uspto-grants-1989_07
- 특허 번호
- US04849424
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