Sodium Carbonate → Ganglioside GM1

HRID 231812

반응식

CC[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([NH:22][C@@H:23]([C@@H:93]([OH:111])/[CH:94]=[CH:95]/[CH2:96][CH2:97][CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH2:104][CH2:105][CH2:106][CH2:107][CH2:108]CC)[CH2:24][O:25][C@@H:26]1[O:31][C@H:30]([CH2:32][OH:33])[C@@H:29]([O:34][C@@H:35]2[O:40][C@H:39]([CH2:41][OH:42])[C@H:38]([O:43][C@@H:44]3[O:49][C@H:48]([CH2:50][OH:51])[C@H:47]([OH:52])[C@H:46]([O:53][C@@H:54]4[O:59][C@H:58]([CH2:60][OH:61])[C@H:57]([OH:62])[C@H:56]([OH:63])[C@H:55]4[OH:64])[C@H:45]3[NH:65][C:66]([CH3:68])=[O:67])[C@H:37]([O:69][C@@:70]3([C:87]([OH:89])=[O:88])[O:75][C@@H:74]([C@H:76]([OH:81])[C@H:77]([OH:80])[CH2:78][OH:79])[C@H:73]([NH:82][C:83]([CH3:85])=[O:84])[C@@H:72]([OH:86])[CH2:71]3)[C@H:36]2[OH:90])[C@H:28]([OH:91])[C@H:27]1[OH:92])=[O:21].C([O-])([O-])=O.[Na+].[Na+]>>[CH3:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([NH:22][C@H:23]([C@H:93]([OH:111])/[CH:94]=[CH:95]/[CH2:96][CH2:97][CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH2:104][CH2:105][CH2:106][CH2:107][CH3:108])[CH2:24][O:25][C@@H:26]1[O:31][C@H:30]([CH2:32][OH:33])[C@@H:29]([O:34][C@@H:35]2[O:40][C@H:39]([CH2:41][OH:42])[C@H:38]([O:43][C@@H:44]3[O:49][C@H:48]([CH2:50][OH:51])[C@H:47]([OH:52])[C@H:46]([O:53][C@@H:54]4[O:59][C@H:58]([CH2:60][OH:61])[C@H:57]([OH:62])[C@H:56]([OH:63])[C@H:55]4[OH:64])[C@H:45]3[NH:65][C:66]([CH3:68])=[O:67])[C@H:37]([O:69][C@@:70]3([C:87]([OH:89])=[O:88])[O:75][C@@H:74]([C@H:76]([OH:81])[C@H:77]([OH:80])[CH2:78][OH:79])[C@H:73]([NH:82][C:83]([CH3:85])=[O:84])[C@@H:72]([OH:86])[CH2:71]3)[C@H:36]2[OH:90])[C@H:28]([OH:91])[C@H:27]1[OH:92])=[O:21]

참가 물질

반응물 2

HCID 10340Sodium Carbonate

HCID 6473724Ganglioside gm1,ammonium salt,bovine

생성물 1

HCID 9963963Ganglioside GM1

실험 절차

IR spectroscopic examination on KBr pellets shows the typical band of the ester at 1750 cm-1. Chromatographic analysis of the product carried out in the same way as in Example 1 shows the presence of a unitary compound with an Rf of 0.89 and the absence of GM1 ganglioside and its internal ester (Rf 0.65 and 0.75, respectively). Hydrolysis with Na2CO3 as described in Example 1 produces the ganglioside GM1.

출처 및 근거

ORD 기록: ord-6db87d5d814b4dc6be33953f2b53f2cd
출처 데이터셋: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04849413

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