Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 2-Imidazolyl-4,6-dichloropyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Imidazolyl-4,6-dichloropyrimidine | HCID 22170001 | — |
반응 단계
One equivalent of imidazole is added in one portion to a solution of one equivalent of trichloropyrimidine and 1.5 equivs of triethylamine in THF. After reaction is complete, the reaction mixture is poured into saturated, aqueous ammonium chloride and extracted three times with ethyl acetate. The combined organic layers are washed with brine and dried. The reaction mixture is filtered and all volatiles removed under reduced pressure. The product, 2-imidazolyl-4,6-dichloropyrimidine (the compound of formula (VIIIa)) is isolated by flash chromatography (20% ethyl acetate in hexane) as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849739B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-e92879e3496d4112afd23c6d1dc6781a |
| 출처 메모 | uspto-grants-2005_02 |