Water → [2-(Trifluoromethyl)-1H-indol-3-yl]methanol

HRID 231836

반응식

HRID 231836 반응식
[BH4-].[K+].[F:3][C:4]([F:17])([F:16])[C:5]1[NH:6][C:7]2[C:12]([C:13]=1[CH:14]=[O:15])=[CH:11][CH:10]=[CH:9][CH:8]=2.O1CCCC1.O>CCOCC>[F:17][C:4]([F:3])([F:16])[C:5]1[NH:6][C:7]2[C:12]([C:13]=1[CH2:14][OH:15])=[CH:11][CH:10]=[CH:9][CH:8]=2

참가 물질

6

반응물 4

HCID 962WaterHCID 8028Tetrahydrofuran2회HCID 4192641Potassium borohydrideHCID 200321282-trifluoromethyl-3-formyl-(1H)-indole

생성물 1

HCID 20032113[2-(Trifluoromethyl)-1H-indol-3-yl]methanol수율 64.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

2 g of potassium borohydride were added in small fractions at +5° C. to a solution of 4.6 g of the product of Step A, 150 ml of tetrahydrofuran and 30 ml of water and the mixture was stirred for one hour. The mixture was allowed to return to ambient temperature and the tetrahydrofuran was eliminated under reduced pressure. The resulting mixture was diluted with ether, washed with water, dried and concentrated under reduced pressure. The residue was chromatographed over silica (eluent: hexaneethyl acetate 7-3) to obtain 3 g of 2-trifluoromethyl-(1H)-indol-3-yl methanol melting at 106° C.

후처리

  1. customto return to ambient temperature
  2. washwashed with water
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was chromatographed over silica (eluent: hexaneethyl acetate 7-3)

출처 및 근거

ORD 기록
ord-ad967951fb5a48f7bfe9f3319054f3fa
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04849443

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