Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Proline, ethyl ester → HCID 131716003, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Proline, ethyl ester | HCID 79888 | — |
| 반응물 | 1-[(S)-6-[(Trifluoroacetyl)amino]-2-[[[1-[[(phenylmethoxy)carbonyl]amino]pentyl]methoxyphosphinyl]oxy]-1-oxohexyl]-L-proline, ethyl ester | HCID 131716004 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 131716003 | HCID 131716003 | — |
반응 단계
The ethyl ester product from part (e) (1.75 g., 2.63 mmole) is dissolved in methanol (75 ml.) at room temperature under argon. The solution is hydrogenated with 20% palladium hydroxide on carbon catalyst (300 mg.) at room temperature and atmospheric pressure for 3 hours. The reaction is filtered through Celite to remove the catalyst, and the volatiles are evaporated to give 1.7 g. of 1-(S)-6-[(Trifluoroacetyl)amino]-2-[[[(1-amino)pentyl]methoxyphosphinyl]oxy]-1-oxohexyl]-L-proline, ethyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04849414 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-27c87647c46d4e8fbbafb6437f0685fc |
| 출처 메모 | uspto-grants-1989_07 |