Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 231965생성일: 2026년 10월 26일
Chlorine → 4-Nitrobenzyl 3-(3-carboxyphenoxy)-2-(4(S)-chloro-3(S)-(1(R)-hydroxyethyl)azetidin-2-on-1-yl)-3-trimethylacetylthiopropenoate
https://huagongshe.com/reaction/231965
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chlorine | HCID 24526 | — |
| 반응물 | 4-nitrobenzyl 3-(3-carboxyphenoxy)-2-(4(R)-ethylthio-3(S)-[1(R)-hydroxyethyl]azetidin-2-on-1-yl)-3-trimethylacetylthiopropenoate | HCID 86743250 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 용매 | Chloroform-D | HCID 71583 | — |
| 생성물 | 4-Nitrobenzyl 3-(3-carboxyphenoxy)-2-(4(S)-chloro-3(S)-(1(R)-hydroxyethyl)azetidin-2-on-1-yl)-3-trimethylacetylthiopropenoate | HCID 86743249 | 87.3% |
반응 단계
To a stirred solution of 5.5 g of 4-nitrobenzyl 3-(3-carboxyphenoxy)-2-(4(R)-ethylthio-3(S)-[1(R)-hydroxyethyl]azetidin-2-on-1-yl)-3-trimethylacetylthiopropenoate in 50 ml of dry deuterochloroform at -40° C. was added a solution of 10.6 mmol of chlorine in carbon tetrachloride. The mixture was stirred for a further 30 minutes at -40° C., and for 30 minutes at room temperature, and was evaporated in vacuo. Chromatography of the residue over silica gel, and elution with hexane-ethyl acetate-formic acid mixtures afforded 4.6 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04849419 |
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| 출처 데이터셋 | uspto-grants-1989_07 |
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| ORD ID | ord-8ff1eeab135845bdbb2d2bdae8541ff1 |
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| 출처 메모 | uspto-grants-1989_07 |
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