Thionyl Chloride → 2,3,4-Trichloro-5-fluorobenzoyl chloride

반응식

[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([Cl:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([Cl:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:16])=[O:5]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 141498672,3,4-Trichloro-5-fluorobenzoic acid

생성물 1

HCID 141498692,3,4-Trichloro-5-fluorobenzoyl chloride

실험 절차

737 g (3.02 mols) of 2,3,4-trichloro-5-fluorobenzoic acid are introduced into 1.5 liters of thionyl chloride at room temperature, and the mixture is refluxed for 16 hours until the gas evolution ceases. Excess thionyl chloride is removed by distillation, and the residue is distilled.

후처리

temperaturethe mixture is refluxed for 16 hours until the gas evolution ceases
customExcess thionyl chloride is removed by distillation
distillationthe residue is distilled

출처 및 근거

ORD 기록: ord-3fbc7edb034d43bf846303d406b61176
출처 데이터셋: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04851160

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