Thionyl Chloride → Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-

HRID 231996

반응식

HRID 231996 반응식
[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([Cl:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>CN(C)C=O>[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([Cl:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4]([Cl:18])=[O:5]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 27342592,4-Dichloro-5-fluoro-3-nitrobenzoic acid

생성물 1

HCID 11818130Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

254 g (1 mol) of 2,4-dichloro-5-fluoro-3-nitrobenzoic acid are refluxed in 700 ml of thionyl chloride with addition of 3 drops of dimethylformamide until the gas evolution ceases. Excess thionyl chloride is removed by distillation, and the residue is fractionated in vacuo.

후처리

  1. customExcess thionyl chloride is removed by distillation

출처 및 근거

ORD 기록
ord-7393af94a2b148a98950d68bf3c02574
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851160

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