Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Dihydroxybutanedioic Acid → HCID 178424608, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| 반응물 | 3-(4-Piperidinomethylpyrazol-1-yloxy)propylamine | HCID 13823214 | — |
| 반응물 | HCID 178503537 | HCID 178503537 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | HCID 178424608 | HCID 178424608 | — |
반응 단계
3.5 g of 3-(4-piperidinomethylpyrazol-1-yloxy)propylamine and 3.6 g of 2-methylthio-5-(2-methylpyrid-5-ylmethyl)-1H-pyrimid-4-one in 30 ml of pyridine are refluxed for 30 hours. The pyridine is distilled off and the residue is then chromatographed over neutral Al2O3 (activity level III) using methylene chloride/3% strength methanol as the mobile phase. The oil obtained is reacted with tartaric acid in isopropanol to give an amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04851410 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-e8522393088a431c8f6a3da6b41f6ee4 |
| 출처 메모 | uspto-grants-1989_07 |