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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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[1-Methyl-2-[[(3-methyl-1-(phenylmethyl)-3-pyrrolidinyl)methyl]amino]-2-oxoethyl]carbamic acid, 1,1-dimethylethyl ester → [1-Methyl-2-[[(3-methyl-3-pyrrolidinyl)methyl]amino]-2-oxoethyl]carbamic acid, 1,1-dimethylethyl ester

HRID 232055
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HRID 232055 반응식
[CH3:1][CH:2]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:3]([NH:5][CH2:6][C:7]1([CH3:19])[CH2:11][CH2:10][N:9](CC2C=CC=CC=2)[CH2:8]1)=[O:4].[H][H]>CO.[Pd]>[CH3:1][CH:2]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:3]([NH:5][CH2:6][C:7]1([CH3:19])[CH2:11][CH2:10][NH:9][CH2:8]1)=[O:4]
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참가 물질

5

반응물 2

HCID 14555506[1-Methyl-2-[[(3-methyl-1-(phenylmethyl)-3-pyrrolidinyl)methyl]amino]-2-oxoethyl]carbamic acid, 1,1-dimethylethyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 14555508[1-Methyl-2-[[(3-methyl-3-pyrrolidinyl)methyl]amino]-2-oxoethyl]carbamic acid, 1,1-dimethylethyl ester수율 96.7%

시약·촉매·용매 2

HCID 23938Palladium촉매
HCID 887
Methanol
용매

실험 절차

A solution of 23.1 g (61.6 mmol) of [1-methyl-2-[[(3-methyl-1-(phenylmethyl)-3-pyrrolidinyl)methyl]-amino]-2-oxoethyl]carbamic acid, 1,1-dimethylethyl ester in 400 ml of methanol was treated with 3.0 g of 20% palladium on carbon and shaken in a hydrogen atmosphere at temperatures of 22°-26° and pressures of 48.7-53.4 psi for 2.5 hours. The catalyst was removed by filtering through celite and the filtrate was evaporated in vacuo to give 17.0 g of the title compound.

후처리

  1. customThe catalyst was removed
  2. filtrationby filtering through celite
  3. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-e58a1ba47d80457ebf084c8ccda6ed13
출처 데이터셋
uspto-grants-1989_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04851418

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