Ammonia → HCID 20031029, 화합물

HRID 232091노트

반응식

HRID 232091 반응식
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:13]=2[F:19])[CH:10]=1)=O)C.[NH3:20]>CO>[F:19][C:13]1[C:14]([F:18])=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][N:9]1[CH:10]=[C:6]([C:4]([NH2:20])=[O:3])[N:7]=[CH:8]1

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 54235425HCID 54235425, 화합물

생성물 1

HCID 20031029HCID 20031029, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5.34 g of 1-(2,3-difluorobenzyl)-imidazole-4-carboxylic acid ethyl ester are dissolved in 80 ml of methanol and transferred to an autoclave. 20.0 g of ammonia are introduced under pressure and the whole is heated at 100° for 19 hours. When the excess ammonia has been blown off, the resulting product is filtered off and recrystallised from ethanol. 1-(2,3-difluorobenzyl)-imidazole-4-carboxamide having a melting point of 221°-222° is obtained.

후처리

  1. temperaturethe whole is heated at 100° for 19 hours
  2. filtrationthe resulting product is filtered off
  3. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-b280689a2e9d4a8081c31ecf41ea09c3
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851424

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