Thionyl Chloride → HCID 14798665, 화합물

HRID 232200노트

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HRID 232200 반응식
O=[C:2]([CH2:7][CH2:8][C:9]([O-:11])=[O:10])[C:3]([O:5][CH3:6])=[O:4].S(Cl)([Cl:14])=O>ClCCl.CN(C)C=O>[Cl:14][C:2]1([C:3]([O:5][CH3:6])=[O:4])[CH2:7][CH2:8][C:9](=[O:10])[O:11]1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 22166434HCID 22166434, 화합물

생성물 1

HCID 14798665HCID 14798665, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

In 10 ml of dichloromethane was dissolved 1.0 g of Compound (10). To the solution were added 911 μl of thionyl chloride and one drop of N,N-dimethylformamide. The mixture was stirred at room temperature for 15 hours. The reaction solution was concentrated. The concentrate was subjected to a flash chromatography using silica gel, followed by elution with hexane-ethyl acetate (1:2) to give 985 mg of the subject Compound (13).

후처리

  1. concentrationThe reaction solution was concentrated
  2. washfollowed by elution with hexane-ethyl acetate (1:2)

출처 및 근거

ORD 기록
ord-0d105a575c56437eba7cd942398fe09e
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851422

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