Thionyl Chloride → HCID 20030906, 화합물

HRID 232215노트

반응식

HRID 232215 반응식
[C:1]1([CH:7]([C:24]([O-:26])=[O:25])[CH2:8][C:9](=O)[C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=2)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:29])=O>ClCCCl>[Cl:29][C:9]1([C:10]([O:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=2)=[O:11])[CH2:8][CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:24](=[O:25])[O:26]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 67902354HCID 67902354, 화합물

생성물 1

HCID 20030906HCID 20030906, 화합물

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

In 4 ml of 1,2-dichloroethane was dissolved 100 mg of the Compound 62 obtained in Example 62. To the solution was added 0.1 ml of thionyl chloride, and the mixture was heated for 4 hours under reflux. The solvent was evaporated off, then the residue was chromatographed on Florisil, followed by elution with hexane-ethyl acetate (2:1) to give 63 mg of the subject Compound (63) as pale yellow crystals.

후처리

  1. temperaturethe mixture was heated for 4 hours
  2. temperatureunder reflux
  3. customThe solvent was evaporated off
  4. customthe residue was chromatographed on Florisil
  5. washfollowed by elution with hexane-ethyl acetate (2:1)

출처 및 근거

ORD 기록
ord-771c7dcaaac74f898f099c9e9636ccfd
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851422

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