Dicyclohexylcarbodiimide → HCID 67901861, 화합물

HRID 232230노트

반응식

HRID 232230 반응식
[CH3:1][O:2][CH:3]([C:20]([O-:22])=[O:21])[CH2:4][C:5](=O)[C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1)=[O:7].[CH2:23]([O:30][C:31]([NH:33][C@H:34]1[CH2:38][O:37][NH:36][C:35]1=[O:39])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C1CCC(N=C=NC2CCCCC2)CC1>ClCCl>[CH2:23]([O:30][C:31]([NH:33][C@H:34]1[CH2:38][O:37][N:36]([C:5]2([C:6]([O:8][CH2:9][C:10]3[CH:11]=[CH:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=3)=[O:7])[CH2:4][CH:3]([O:2][CH3:1])[C:20](=[O:21])[O:22]2)[C:35]1=[O:39])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 14181640HCID 14181640, 화합물HCID 67902313HCID 67902313, 화합물

생성물 1

HCID 67901861HCID 67901861, 화합물수율 47.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In 10 ml of dichloromethane was dissolved 896 mg of Compound (93). To the solution were added 680 mg of (4S)-4-benzyloxycarbonylamino-3-isoxazolidinone and 593 mg of DCC, and the mixture was stirred at room temperature for one hour. Then, precipitating crystals were filtered off, and the solvent was evaporated off. The residue was subjected to a silica gel column chromatography, followed by elution with hexane--ethyl acetate (3:2) to give 723 mg of the subject Compound (94) as an oily product.

후처리

  1. customThen, precipitating crystals
  2. filtrationwere filtered off
  3. customthe solvent was evaporated off
  4. washfollowed by elution with hexane--ethyl acetate (3:2)

출처 및 근거

ORD 기록
ord-9f9d8d815f4145bbbbf55d6f45a20a66
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851422

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