Dichloromethane → 5-Chloro-7-(2-fluoro-4-iodo-phenylamino)-pyrrolo[1,2-c]pyrimidine-6-carboxylic acid

반응식

[B:24]([Br:25])([Br:26])[Br:27].[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([Cl:23])[c:7]2[n:8]([cH:9][n:10][cH:11][cH:12]2)[c:13]1[NH:14][c:15]1[c:16]([F:22])[cH:17][c:18]([I:21])[cH:19][cH:20]1.[Cl:28][CH2:29][Cl:30]>>[O:2]=[C:3]([OH:4])[c:5]1[c:6]([Cl:23])[c:7]2[n:8]([cH:9][n:10][cH:11][cH:12]2)[c:13]1[NH:14][c:15]1[c:16]([F:22])[cH:17][c:18]([I:21])[cH:19][cH:20]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 672349105-Chloro-7-(2-fluoro-4-iodo-phenylamino)-pyrrolo[1,2-c]pyrimidine-6-carboxylic acid methyl ester

생성물 1

HCID 672348605-Chloro-7-(2-fluoro-4-iodo-phenylamino)-pyrrolo[1,2-c]pyrimidine-6-carboxylic acid

출처 및 근거

ORD 기록: ord-f50100db9ea24f30aae5d67b29da8659
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

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