Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1,2-Diethyl-4-piperidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 반응물 | 1-Propanamine, N-ethyl- | HCID 88398 | — |
| 반응물 | 2-(Trimethylsiloxy)-1,3-butadiene | HCID 554657 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1,2-Diethyl-4-piperidinone | HCID 20031315 | — |
반응 단계
To 100 mL of methylene chloride cooled to 0° C. is added 2-(trimethylsilyloxy)-1,3-butadiene (14.2 g, 0.1 mol), 8.5 g (0.1 mol) of N-ethyl-propanamine, and 14.2 g (0.1 mol) of borontrifluoride etherate. Monitor the reaction by thinlayer chromatography. Upon completion add 1N HCl until gas evolution ceases. Separate the aqueous layer and make it alkaline with 1N NaOH. Extract twice with 100 mL ether and dry over Na2SO4. Filter the drying agent and evaporated the solvent in vacuo to obtain the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04851526 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-dc7eb3e1a8054954978500e3c6bd556b |
| 출처 메모 | uspto-grants-1989_07 |