Methanol → 4-[[2-(3,4,5-Trimethoxyphenyl)ethyl](methyl)amino]hexan-3-ol

HRID 232280

반응식

HRID 232280 반응식
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[C:9](OC)[C:8]([O:13][CH3:14])=[C:7]([O:15][CH3:16])[CH:6]=1.[CH2:17]([CH:19]1[CH:21]([CH2:22][CH3:23])[O:20]1)[CH3:18].[CH3:24][OH:25]>>[CH3:24][O:25][C:9]1[CH:10]=[C:5]([CH2:4][CH2:3][N:2]([CH3:1])[CH:21]([CH2:22][CH3:23])[CH:19]([OH:20])[CH2:17][CH3:18])[CH:6]=[C:7]([O:15][CH3:16])[C:8]=1[O:13][CH3:14]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1382642,3-DiethyloxiraneHCID 138365N-Methylmescaline

생성물 1

HCID 200313814-[[2-(3,4,5-Trimethoxyphenyl)ethyl](methyl)amino]hexan-3-ol

실험 절차

Combine 22.5 g (0.1 mol) of N-methyl-3,4,5-trimethoxybenzeneethanamine and 10 g (0.1 mol) of 2,3-diethyloxirane in 150 mL of 90% aqueous methanol. Heat the reaction at 50° C. and follow the progress of the reaction by thin-layer chromatography. At the completion of the reaction remove the solvent in vacuo and chromatograph the residue on silica gel to obtain the title compound.

후처리

  1. temperatureHeat
  2. customthe reaction at 50° C.
  3. customthe progress of the reaction by thin-layer chromatography
  4. customAt the completion of the reaction remove the solvent in vacuo and chromatograph the residue on silica gel

출처 및 근거

ORD 기록
ord-9557d6b1d5794e29856206cf104fc55c
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

연결된 노트

불러오는 중…