Butyl iodide → HCID 20031349, 화합물

HRID 232302노트

반응식

HRID 232302 반응식
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]([C:8]#[N:9])[CH2:2]1.I[CH2:11][CH2:12][CH2:13][CH3:14]>C(#N)C>[CH2:11]([N:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]([C:8]#[N:9])[CH2:2]1)[CH2:12][CH2:13][CH3:14]

참가 물질

4

반응물 2

HCID 10962Butyl iodideHCID 13498182HCID 13498182, 화합물

생성물 1

HCID 20031349HCID 20031349, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To 50 mL of acetonitrile is added 1 g (8.0 mmol) of hexahydro-1H-azepine-3-carbonitrile and 2.7 g (15 mmol) of iodobutane. Heat the reaction under reflux and monitor the reaction by thin-layer chromatography. Upon completion remove the solvent in vacuo and add 50 mL sat. sodium bicarbonate and 50 mL methylene chloride. Separate the organic layer and dry over Na2SO4. Filter off the drying agent and remove the solvent in vacuo to obtain the title compound.

후처리

  1. temperatureHeat
  2. customthe reaction
  3. temperatureunder reflux
  4. customthe reaction by thin-layer chromatography
  5. customUpon completion remove the solvent in vacuo
  6. additionadd 50 mL sat. sodium bicarbonate and 50 mL methylene chloride
  7. customSeparate the organic layer
  8. dry with materialdry over Na2SO4
  9. filtrationFilter off the drying agent
  10. customremove the solvent in vacuo

출처 및 근거

ORD 기록
ord-80e0c4ba2f7e491a9d970aac7c67dcad
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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