Diethylamine → HCID 20031339, 화합물

HRID 232305노트

반응식

HRID 232305 반응식
CS(O[CH2:6][CH:7]1[CH2:9][CH:8]1[C:10]#[N:11])(=O)=O.[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>CO>[CH2:12]([N:14]([CH2:6][CH:7]1[CH2:9][CH:8]1[C:10]#[N:11])[CH2:15][CH3:16])[CH3:13]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 20031330HCID 20031330, 화합물

생성물 1

HCID 20031339HCID 20031339, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 10 mL of methanol add 1.75 g (2.10 mmol) of 2-[[(methylsulfonyl)oxy]methyl]cyclopropanecarbonitrile and 2.0 g (27 mmol) of diethylamine. Reflux the reaction and monitor by thin-layer chromatography. Upon completion remove the solvent in vacuo and add 50 mL methylene chloride and 50 mL sat. sodium carbonate. Separate the organic layer and dry over Na2SO4. Filter the drying agent and remove the solvent in vacuo to obtain the title compound.

후처리

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customUpon completion remove the solvent in vacuo
  4. additionadd 50 mL methylene chloride and 50 mL sat. sodium carbonate
  5. customSeparate the organic layer
  6. dry with materialdry over Na2SO4
  7. filtrationFilter the drying agent
  8. customremove the solvent in vacuo

출처 및 근거

ORD 기록
ord-7625e6a393a94d918be54bfae1662d0b
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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