HCID 18633461, 화합물 → HCID 15460476, 화합물

HRID 232374노트

반응식

HRID 232374 반응식
[N:1]([CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:17]=[C:16]([CH2:18][CH3:19])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[C@@H:7]([F:20])[C@@H:6]1[OH:21])=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:17]=[C:16]([CH2:18][CH3:19])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[C@@H:7]([F:20])[C@@H:6]1[OH:21]

참가 물질

4

반응물 1

HCID 18633461HCID 18633461, 화합물

생성물 1

HCID 15460476HCID 15460476, 화합물수율 82.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 0.4 g of 1-(5-azido-2,5-dideoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil in 20 ml of ethanol was hydrogenated at room temperature and under atmospheric pressure in the presence of 0.1 g of 10% palladium-on-carbon catalyst for 24 hours. The catalyst was removed by filtration and the filtrate was evaporated. The residue was triturated with diethyl ether and the solid was removed by filtration, washed with ethyl acetate and dried in vacuo to give 0.3 g of 1-(5-amino-2,5-dideoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil as a white solid.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated
  3. customThe residue was triturated with diethyl ether
  4. customthe solid was removed by filtration
  5. washwashed with ethyl acetate
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-65ef55b7962348c491271d3593de0b82
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851519

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