(3,4-Dichlorophenyl)acetonitrile → 2,4-Diamino-5-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

HRID 232610

반응식

HRID 232610 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[C:11]([Cl:16])[C:10]=2Cl)=[C:4]([C:18]([F:21])([F:20])[F:19])[N:3]=1.[Cl:22]C1C=C(CC#N)C=CC=1Cl>CO.C(Cl)(Cl)Cl>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:22])=[C:11]([Cl:16])[CH:10]=2)=[C:4]([C:18]([F:20])([F:21])[F:19])[N:3]=1

참가 물질

4

반응물 2

HCID 76690(3,4-Dichlorophenyl)acetonitrileHCID 117727232,4-Diamino-5-(2,3,5-trichlorophenyl)-6-trifluoromethylpyrimidine

생성물 1

HCID 197051142,4-Diamino-5-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

시약·촉매·용매 1

HCID 21584188Chloroform methanol용매

실험 절차

This compound was made in an analogous manner to the compound of Example 4, from 3,4-dichlorophenylacetonitrile (Aldrich) mp. 252°-254.5° C.: TLC (SiO2 ; methanol/chloroform, 1:9) Rf=0.38.

출처 및 근거

ORD 기록
ord-ff446b250d834a2493964e7cab0d71cc
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591746

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