Dichloromethane → 2-(4-(4-Aminopiperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

반응식

[Cl:41][CH2:42][Cl:43].[F:1][c:2]1[c:3](-[c:9]2[n:10][c:11]3[cH:12][c:13]([CH3:33])[cH:14][cH:15][c:16]3[c:17]([N:19]3[CH2:20][CH2:21][CH:22]([NH:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:23][CH2:24]3)[n:18]2)[c:4]([OH:8])[cH:5][cH:6][cH:7]1.[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40]>>[F:1][c:2]1[c:3](-[c:9]2[n:10][c:11]3[cH:12][c:13]([CH3:33])[cH:14][cH:15][c:16]3[c:17]([N:19]3[CH2:20][CH2:21][CH:22]([NH2:25])[CH2:23][CH2:24]3)[n:18]2)[c:4]([OH:8])[cH:5][cH:6][cH:7]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 136121470Tert-butyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)piperidin-4-ylcarbamate

생성물 1

HCID 1361213392-(4-(4-Aminopiperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

출처 및 근거

ORD 기록: ord-a9576815ca084678a16ba4d057053426
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

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