p-Toluenesulfonic acid → Ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate

HRID 232656

반응식

HRID 232656 반응식
[CH3:1][C:2]1[C:7]([C:8]([CH:10](C(OCC)=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:7]([C:8]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 53783746Diethyl 6-methyl-2,3,4,5-tetrafluorobenzoylmalonate

생성물 1

HCID 14774100Ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate수율 70.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To diethyl 6-methyl-2,3,4,5-tetrafluorobenzoyl-malonate (8 g) are added water (20 ml) and p-toluenesulfonic acid (80 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate (4.5 g).

후처리

  1. temperaturethe mixture is refluxed for 2.5 hours
  2. temperatureAfter cooling
  3. extractionthe resultant is extracted with diethyl ether
  4. dry with materialthe extract is dried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fc1a13fa43534541b6407e093912808b
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591744

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