Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-5-chlorothiophene-2-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-5-chlorothiophene-2-sulfonyl chloride | HCID 2797220 | — |
| 반응물 | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| 생성물 | N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide | HCID 15342063 | 25% |
반응 단계
N-(4-Bromo-3-methyl-5-isoxazolyl)-4-bromo-5-chloro-thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 4-bromo-5-chlorothiophene-2-sulphonyl chloride in 25% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 143°-145° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05591761 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-b36f574adcf54b81930a0f8630ee57dc |
| 출처 메모 | uspto-grants-1997_01 |