Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Allyl bromide → 1-[3alpha,17beta-Dihydroxy-2beta-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-5alpha-androstane-16beta-yl]-1-(2-propenyl)pyrrolidinium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Allyl bromide | HCID 7841 | — |
| 반응물 | 2beta-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-16beta-(1-pyrrolidinyl)-5alpha-androstane-3alpha,17beta-diol | HCID 22868545 | — |
| 생성물 | 1-[3alpha,17beta-Dihydroxy-2beta-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-5alpha-androstane-16beta-yl]-1-(2-propenyl)pyrrolidinium bromide | HCID 67684035 | 82% |
반응 단계
2β-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-16β-(1-pyrrolidinyl)-5α-androstane-3α,17β-diol is reacted with allyl bromide as described in Example 5 to obtain the title compound in a yield of 82%, m.p.: 238°-240° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05591735 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-f08f0ff41dae412ea28d0eb683bd7670 |
| 출처 메모 | uspto-grants-1997_01 |