7-Chloro-6-fluoro-2-formylquinoline → (7-Chloro-6-fluoroquinolin-2-yl)methanol

HRID 232866

반응식

HRID 232866 반응식
B.[Na].[Cl:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10]([CH:14]=[O:15])=[N:11]2)=[CH:6][C:5]=1[F:16]>CO>[Cl:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10]([CH2:14][OH:15])=[N:11]2)=[CH:6][C:5]=1[F:16]

참가 물질

4

반응물 2

HCID 233591737-Chloro-6-fluoro-2-formylquinolineHCID 178418435HCID 178418435, 화합물

생성물 1

HCID 23359111(7-Chloro-6-fluoroquinolin-2-yl)methanol수율 69.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3 g of sodium boron hydride was added to 11.19 g of 7-chloro-6-fluoro-2-formylquinoline obtained in Reference example 2 suspended in 250 ml of methanol and the mixture was stirred at room temperature for 1 hour. After the solvent was removed, the residue was extracted with ice water-methylene chloride and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was applied to silica gel column chromatography to obtain 7.84 g of the title compound.

후처리

  1. customobtained in Reference example 2
  2. customAfter the solvent was removed
  3. extractionthe residue was extracted with ice water-methylene chloride
  4. washthe organic layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customAfter the solvent was removed

출처 및 근거

ORD 기록
ord-20468624d1b34544a12da48e15e04df3
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05591752

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