반응식
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15]([CH2:19][O:20][C:21]3[CH:47]=[CH:46][C:24]4[O:25][CH2:26][C:27]5[CH:40]=[C:39]([CH2:41][CH2:42][C:43](=[O:45])[CH3:44])[CH:38]=[CH:37][C:28]=5[CH:29]([O:30]C5CCCCO5)[C:23]=4[CH:22]=3)=[N:16]2)=[CH:11][C:10]=1[F:48].C(O)(=O)C>O1CCOCC1.O>[Cl:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15]([CH2:19][O:20][C:21]3[CH:47]=[CH:46][C:24]4[O:25][CH2:26][C:27]5[CH:40]=[C:39]([CH2:41][CH2:42][C:43](=[O:45])[CH3:44])[CH:38]=[CH:37][C:28]=5[CH:29]([OH:30])[C:23]=4[CH:22]=3)=[N:16]2)=[CH:11][C:10]=1[F:48]참가 물질
반응물 3
생성물 1
시약·촉매·용매 2
실험 절차
0.02 ml of trifluoroacetic acid was added to 0.73 g of 2-(7-chloro-6-fluoroquinolin-2-yl)methoxy-8-(2-acetylethyl)-11-(2-tetrahydropyranyloxy)-6,11-dihydrodibenz[b,e]oxepine obtained in Reference example 74 dissolved in a mixed solution of 5 ml of dioxane and 2 ml of water, the mixture was stirred at room temperature for 15 minutes, 4 ml of acetic acid was added to the mixture and the mixture was stirred for 10 hours. 80 ml of water was added to the reaction mixture and insolubles were removed by filtration. The residue was dissolved in chloroform and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was washed with a mixed solution of acetone and ether to obtain 0.41 g of the title compound.
후처리
- customobtained in Reference example 74
- stirringthe mixture was stirred for 10 hours
- customwere removed by filtration
- dissolutionThe residue was dissolved in chloroform
- washthe organic layer was washed with water
- dry with materialdried over anhydrous sodium sulfate
- customAfter the solvent was removed
- washthe residue was washed with a mixed solution of acetone and ether
출처 및 근거
- ORD 기록
- ord-ba4536a181754e39a127951667b20ab4
- 출처 데이터셋
- uspto-grants-1997_01
- 특허 번호
- US05591752
연결된 노트
불러오는 중…